Enfamil ProSobee vs Gerber Good Start SoothePro (2026): Which Formula Is Better?
A dairy-free soy formula versus a gentle cow's milk formula built specifically for colic — two different strategies for uncomfortable babies. We break down protein sources, colic-specific features, pricing, and which situation calls for which formula.
Enfamil ProSobee at a Glance
Enfamil ProSobee costs approximately $25 per 12.9 oz can and is a soy protein-based infant formula that eliminates all dairy and lactose. It was designed for babies with lactose intolerance, families choosing dairy-free feeding, or as an alternative protein source when cow's milk is being avoided for non-allergy medical reasons.
- Protein: soy protein isolate — complete plant protein, entirely dairy-free
- Carbohydrate: corn syrup solids (100% lactose-free)
- Fat blend: palm olein, soy, coconut, and high oleic sunflower oils with added DHA and ARA
- Contains a dual-prebiotic blend (polydextrose and GOS) but no probiotics
- 20 calories per fluid ounce at standard dilution; meets all FDA requirements for complete infant nutrition
Gerber Good Start SoothePro at a Glance
Gerber Good Start SoothePro retails for approximately $32 per 19.4 oz canister. It is Gerber's most specialized comfort formula, built around 100% partially hydrolyzed whey protein and a combination of ingredients specifically chosen to reduce colic symptoms — excessive crying, fussiness, and gas in otherwise healthy infants.
- Protein: 100% partially hydrolyzed whey from cow's milk — smaller protein fragments that form softer curds in the stomach for faster, easier digestion
- Carbohydrate: corn maltodextrin with reduced lactose (~30% lactose content, lower than standard formula)
- Fat blend: vegetable oils (palm olein, soy, coconut, high oleic safflower) with DHA
- Contains the probiotic L. rhamnosus GG — the most clinically studied probiotic strain for infant colic, with evidence showing reduced daily crying time
- Includes 2'-FL HMO (human milk oligosaccharide), a prebiotic structurally identical to the most abundant oligosaccharide in breast milk
Protein and Digestibility Compared
These formulas take fundamentally different approaches to protein. ProSobee sidesteps dairy entirely with soy. SoothePro keeps dairy but processes it to be gentler. The right approach depends on whether dairy itself is the problem.
- ProSobee's soy protein isolate is intact (not hydrolyzed) — it provides complete nutrition from plant sources and ensures zero exposure to cow's milk protein or lactose
- SoothePro's partially hydrolyzed whey breaks cow's milk whey into smaller fragments that digest faster and produce less gas than intact proteins found in standard formulas
- Whey protein (even partially hydrolyzed) empties from the stomach faster than casein, which may reduce spit-up and reflux symptoms in some colicky babies
- Soy protein tends to produce firmer, more formed stools; partially hydrolyzed whey tends to produce softer, looser stools — neither pattern is a concern
- Neither formula is hypoallergenic: ProSobee contains intact soy allergen, and SoothePro still contains cow's milk protein fragments large enough to trigger CMPA
Colic and Comfort Features
SoothePro was purpose-built for colic with multiple complementary ingredients. ProSobee was not designed as a colic formula but can indirectly help if dairy is the colic trigger.
- SoothePro's L. rhamnosus GG probiotic has been shown in multiple clinical trials to reduce crying time in colicky breastfed and formula-fed infants by an average of 50+ minutes per day
- SoothePro's 2'-FL HMO prebiotic supports development of beneficial gut bacteria (Bifidobacteria), which are associated with less gas production and calmer digestion
- SoothePro's reduced lactose (~30%) lowers the fermentable sugar load in the gut, which can decrease gas and bloating in sensitive infants
- ProSobee eliminates lactose entirely, which can help if lactose fermentation is contributing to colic — but it lacks the probiotic and HMO support that SoothePro provides
- If your baby's colic improved dramatically on ProSobee, that is a strong signal that dairy or lactose was a contributing factor and you may want to discuss allergy testing with your pediatrician
Price, Availability, and Mixing
Both formulas are readily available across the U.S., though they sit at different price points. Here's how daily feeding economics compare.
- ProSobee: ~$25 per 12.9 oz can — approximately $0.19 per prepared fluid ounce
- SoothePro: ~$32 per 19.4 oz canister — approximately $0.16 per prepared fluid ounce, making it slightly cheaper per serving despite the higher sticker price
- Both are available at Walmart, Target, Amazon, grocery stores, and pharmacies with generally reliable stock
- SoothePro dissolves cleanly with minimal foaming; ProSobee can foam slightly when shaken — swirl gently instead of shaking to reduce air bubbles (which can worsen gas)
- Taste: SoothePro has a mildly sweet, relatively neutral flavor; ProSobee has a noticeable soy taste that some babies need a few feedings to accept
Which Formula Should You Choose?
The decision between ProSobee and SoothePro depends on whether your baby's discomfort is related to dairy or to broader colic and digestive immaturity.
- Choose SoothePro if your baby has colic, excessive crying, or persistent fussiness and gas without signs of dairy allergy — its probiotic, hydrolyzed whey, and HMO combination directly targets these symptoms
- Choose ProSobee if you suspect dairy or lactose is the root cause of your baby's discomfort, if your baby has confirmed lactose intolerance, or if your family prefers a dairy-free formula
- If your baby is colicky and you've tried a standard gentle formula without improvement, your pediatrician may suggest trying SoothePro first (since most colic is not dairy-related) and switching to ProSobee if symptoms persist
- For babies with both colic symptoms and a family history of dairy allergy, discuss the approach with your pediatrician — a short ProSobee trial can help determine if dairy is the trigger
- If neither SoothePro nor ProSobee resolves severe colic, an extensively hydrolyzed formula like Gerber Extensive HA or Nutramigen may be the next step your doctor recommends